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     Bacitracin is a kind of polypeptide antibiotic acquired from fermented liquid of bacillus licheniformis.It have a strong inhibitory effect for most gram-positive bacterium, such as clostridium, spirochete, and actinomycetes. Because of the instability, bacitracin is made to BACITRACIN METHYLENE DISALICYLATE applied in veterinary clinic, mainly used to prevent and control poultry necrotizing enteritis caused by Clostridium perfringens and Swine dysentery caused by treponema. Although there are lots of research reports in our country about bacitracin zinc additives used in poultry and livestock as growth promoter, there is rarely research report about Bacitracin for prevention and treatment of poultry and livestock disease. By observing the BACITRACIN METHYLENE DISALICYLATE pesticide effect on chicken necrotizing enteritis caused by artificial infection Clostridium perfringens type C, Jianzhong Shen and other professors from the China agricultural university further confirmed the antibacterial effect of bacitracin, which provides scientific basis for this drug application in domestic animal husbandry industry.

       Put Bacitracin Methylene Disalicylate 50% Soluble Powder into high, medium and low three groups, to treat broiler chicken infected with Clostridium perfringens by artificial way. With each dose group of chicken’s morbidity, mortality rate, clinical symptoms, course of disease, and relative weight gain rate etc, separately compare the relevant indicators in control group, negative control group and healthy controls to evaluate the efficacy of Bacitracin Methylene Disalicylate.

       Result shows that the effective concentration of mixed drinks of Bacitracin Methylene Disalicylate is 50-200 mg/kg, of which 100-200 mg/kg - dose of treatment effect is the best which better than the 500 mg/kg - tylosin, further confirmed the therapeutic effect of Bacitracin and its clinical application dose. Bacitracin, therefore, not only can be used as ideal growing additives for poultry and livestock, but also be used to treat chicken necrotic enteritis caused by Clostridium perfringens.  Its clinical effect is reliable, which has wide application prospect.